Fat Chance

Beating the Odds Against Sugar, Processed Food, Obesity, and Disease
by Robert Lustig | Avery © 2013 · 336 pages

Robert Lustig is a Professor of Pediatrics in the Division of Endocrinology and a member of the Institute for Health Policy Studies at University of California, San Francisco. He has authored 120 peer-reviewed articles and 70 reviews and is a leading voice on childhood obesity. And, his YouTube video “Sugar: The Bitter Truth” has been viewed over 7 million times. Obesity is a global pandemic. It’s astonishing how rapidly it’s expanding. And it’s COMPLETELY preventable. Lustig has dedicated his career to helping us understand the causes and how to “beat the odds against sugar, processed food, obesity and disease.” Big Ideas we explore include: Meeting the Darth Vader of the Food Empire (“Hi, sugar!”), two hormones driving the show (insulin + leptin), which fat you need to worry about most (big belly vs. big butt fat!), why so many diets work (reduced sugar + fiber), exercise (best ROI in medicine) and voting with ever dollar we *don’t* spend.


There are only two things that are more important than food: air and water. Shelter’s a distant fourth. Food matters. Unfortunately, food now matters even more than it should. Food is beyond a necessity; it’s also a commodity, and it has been reformulated to be an addictive substance.
Robert Lustig

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“All the major U.S. governmental health agencies, the Centers for Disease Control (CDC), the U.S. Department of Agriculture (USDA), the Institute of Medicine (IOM), the National Institutes of Health (NIH), and the U.S. Surgeon General, say that obesity results from an energy imbalance: eating too many calories and not getting enough physical activity. And they are right—to a point. Are we eating more? Of course. Are we exercising less? No doubt. Despite knowing this, it hasn’t made any difference in the rates of obesity or associated diseases. More to the point, how did this epidemic happen and in such a short interval of just thirty years? People say, ‘The food is there,’ and it is. But it was there before. People say, ‘The TV is there,’ and it is. But it was there before, and we didn’t have this caloric catastrophe. There’s more to this story, way more, and it’s not pretty.

Everyone blames everyone else for what has happened. No way is it their fault. Big food says it’s a lack of activity due to computers and video games. The TV industry says it’s our junk food diet. The Atkins people say it’s too many carbohydrates; the Ornish people say it’s too much fat. The juice people say it’s the soda; the soda people say it’s the juice. The schools say it’s the parents; the parents say it’s the schools. And since nothing is for sure, nothing is done. How do we reconcile all these opinions into a cohesive whole that actually makes sense and creates changes for the better for each individual and for all society? That’s what this book is about.”

~ Robert H. Lustig from Fat Chance

Robert Lustig is a Professor of Pediatrics in the Division of Endocrinology and a member of the Institute for Health Policy Studies at University of California, San Francisco. He has authored 120 peer-reviewed articles and 70 reviews and is a leading voice on childhood obesity.

And, his YouTube video “Sugar: The Bitter Truth” has been viewed over 7 million times.

He’s a colleague of Elizabeth Blackburn and Elissa Epel, who wrote The Telomere Effect. I got this book after they unequivocally agreed with his metabolic theory and the fact that not all calories are alike in their effects on the human body. (Hint: Sugar calories are the worst.)

Our last Note was on Gary Taubes’s The Case Against Sugar. He says this about Lustig: “No scientist has done more in the last fifty years to alert Americans to the potential dangers of sugar in the diet than Dr. Robert Lustig.”

We’re spending so much energy on these books/this topic because it matters. Obesity is a global pandemic. It’s astonishing how rapidly it’s expanding. And it’s COMPLETELY preventable.

The solution isn’t to eat less and exercise more per se, although that’s obviously part of the solution. The most powerful, simple step we can take? Reduce your sugar intake. Throw out the sugary drinks and refined carbs (/carbage!) they come packaged in and reclaim your health.

This book is a comprehensive look at how to, as the sub-title suggests, “beat the odds against sugar, processed food, obesity, and disease.” (Get a copy here.)

Of course, it’s packed with Big Ideas. And, as always, I’m excited to share a few of my favorites we can apply to our lives *today* so let’s jump straight in!

The Darth Vader of the Food Empire

“Second, if a calorie is a calorie, then all fats would be the same because they’d each release 9.0 calories per gram of energy when burned. But they’re not the same. There are good fats (which have valuable properties, such as being anti-inflammatory) and bad fats (which can cause heart disease and fatty liver disease). Likewise, all proteins and amino acids should be the same, since they release 4.1 calories per gram of energy when burned. Except that we have high-quality protein (such as egg protein), which may reduce appetite, and we have low-quality protein (hamburger meat), which is full of branched-chain amino acids, which has been associated with insulin resistance and metabolic syndrome. Finally, all carbohydrates should be the same, since they also release 4.1 calories per gram of energy when burned. But they’re not. A closer look at the specific breakdown of the carbohydrate data reveals something interesting. There are two classes of carbohydrate: starch and sugar. Starch is made up of glucose only, which is not very sweet and which every cell in the body can use for energy. Although there are several other ‘sugars’ (glucose, galactose, maltose, and lactose), when I talk about sugar here (and in the rest of this book), I am talking about the ‘sweet’ stuff, sucrose and high-fructose corn syrup, which both contain the molecule fructose. Fructose is very sweet and is inevitably metabolized to fat. It is the primary (although not sole) villain, the Darth Vader of the Empire, beckoning you to the dark side of this sordid tale.”

That’s from Chapter 2: “A Calories Is a Calorie—or Is It?”

As per the introduction to this Note, all the major U.S. governmental health agencies (from the CDC to the USDA) tell us that the root of our obesity epidemic (and the associated diseases that are killing us like diabetes and heart disease) is the idea that we have an “energy imbalance”—we eat more than we burn; therefore, from this perspective, the solution is simple: all we need to do is eat less and move more and voila! We’d be healthy.

There’s only one little problem with that hypothesis: It’s not true. (Laughing.)

As part of that conventional approach, the dogma is that “a calorie is a calorie.” As part of *that* perspective, conventional thinkers don’t recognize that different calories effect our bodies in different ways. And, as a result of that perspective, they don’t think that sugars are toxic—at the worst, they’re “empty calories.”

But… Lustig is one of the researchers who has been working hard to establish the fact that a calorie is NOT a calorie.

As a leading endocrinologist, he’s been studying how different foods effect the HORMONES within our bodies and tells us that THAT’s where we should be looking for the solution to our problems.

And, guess which foods wreak the most havoc? Yep. Sugars.

P.S. Lustig mentions “good” fats and “bad” fats. The primary bad fats? Trans fats and Omega-6 veggie oils like soybean oil, safflower oil and canola oil (go look at your salad dressings and then throw them out if they have those oils—and most do).

The good fats? We talk about this a lot in Mark Hyman’s Eat Fat, Get Thin. Short story: Olives, olive oil, coconut oil, avocados, fats from whole nuts and seeds. And, these days we’re big fans of algae oil and perilla oil (the primary cooking oil in Asia) at the Johnson house.

Note: If a calorie was a calorie, all fat calories should effect your body in the same way.

But (echo) they don’t.

P.P.S. Elizabeth Blackburn and Elissa Epel refer to Lustig’s research in their book The Telomere Effect when they tell us: “When we want to spot the parties responsible for metabolic disease, we point a finger at the highly processed, sugary foods and sweetened drinks. (We’re looking at you, packaged cakes, candies, cookies, and sodas.) These are the foods and drinks most associated with compulsive eating. They light up the reward system in your brain. They are almost immediately absorbed into the blood, and they trick the brain into thinking we are starving and need more food. While we used to think all nutrients had similar effects on weight and metabolism—a ‘calorie is a calorie’—this is wrong. Simply reducing sugars, even if you eat the same number of calories, can lead to metabolic improvements. Simple carbs wreak more havoc on metabolism and control over appetite than other types of foods.”

Now it’s time to look at some key hormones.

There’s one lesson to conclude from these three contradictions to current dogma: A calorie is not a calorie. Rather, perhaps the dogma should be restated thus: a calorie *is* a calorie burned, but a calorie *is not* a calorie eaten. And therein lies the key to understanding the obesity pandemic.
Robert Lustig
If obesity were just an American phenomenon it would be an epidemic, an outbreak of illness specific to a certain area. One might then blame our American culture for promoting it. Due to our slippage in education and technological superiority, we’re labeled as ‘fat and lazy’ or ‘gluttons and sloths.’ Yet obesity is now a pandemic, a worldwide problem.
Robert Lustig
If you had any residual doubt about ‘a calorie is not a calorie,’ this analysis should remove it. Every additional 150 calories per person per day barely raised diabetes prevalence. But if those 150 calories were instead from a can of soda, increase in diabetes rose sevenfold. Sugar is more dangerous than its calories. Sugar is a toxin. Plain and simple.
Robert Lustig

Insulin: The #1 hormone for fat (+ its BFF Leptin)

“Insulin, in common parlance, is known as the diabetes hormone. Diabetics inject insulin to lower their blood glucose. But where does the glucose go? To the fat. Insulin’s actual job is to be your energy storage hormone. When you eat something (usually containing some form of carbohydrate), your blood glucose rises, signaling the pancreas to release insulin commensurate with the rise in blood glucose. … Insulin then tops off the liver’s energy reserve by making liver starch (called glycogen), and shunts any amino acids from the blood into muscle cells. Excess fatty acids, or blood lipids, are cleared into fat cells for storage for a ‘rainy day,’ where they get turned into greasy triglycerides (such as the fat surrounding your steak). There is no energy storage without insulin—it is the key that unlocks the door to the fat cell to let energy enter and subsequently be stored as fat. Insulin makes fat—the more insulin, the more fat. And there it sits . . . and sits . . . for as long as there is insulin around. When the insulin levels drop, the process goes in reverse: the triglycerides get broken down, causing the fat cells to shrink—when it happens, that’s weight loss!—and the fatty acids reenter the bloodstream and travel back to the liver, where they are burned by the liver or other organs. In this way, by cycling our insulin up and down, we burn what we need, and store the rest.”

Welcome to Chapter 4: “Gluttony and Sloth—Behaviors Driven by Hormones” in which we get a quick science lesson on two of the most important hormones that drive our metabolic health show AND drive our behaviors around eating and moving.

First, we have insulin. As Lustig says: “Insulin makes fat—the more insulin, the more fat.” Get your insulin under control and you Optimize your metabolic health (and weight).

Pop quiz: What drives insulin through the roof more than anything else? Yep. Sugar.

Another hormone that’s actively involved in our “gluttony and sloth” is leptin.

Lustig tells us that “Leptin is a protein made and released by fat cells. It circulates in the bloodstream, goes to the hypothalamus, and signals the hypothalamus that you’ve got enough energy stored up in your fat. The discovery of leptin closed the loop, providing a servomechanism (like your home’s thermostat) in which the body’s fat cells told the hypothalamus whether the animal was in energy surplus (obesity) or dearth (starvation).”

Here’s the problem though: “High insulin blocks the leptin signal, mimicking ‘brain starvation’ … so that we feel hungry even when we have eaten.”

Plus: “Their [obese people’s] hypothalami can’t see their leptin, so their brains think they’re starving and will therefore try to increase energy storage (gluttony) and conserve energy usage (sloth).”

His point with all that?

Once we get our hormones out of whack, it’s REALLY hard to control our behaviors because, although we’re eating a ton (of carbage that jacks up our insulin), our brain basically thinks we’re starving (because it can’t see the leptin) and therefore tells us we need to eat more (enter gluttony) and move less to conserve energy (enter sloth).

So, his advice? Remember that a calories is NOT a calorie. Pick calories that play nice with your hormones. Get them balanced again and you’ll a) want to eat less and b) want to move more.

Vices of gluttony and sloth solved at a biochemical level.

There is no fat accumulation without insulin. Insulin shunts sugar to fat. It makes your fat cells grow. The more insulin, the more fat, period. While there are many causes of obesity, excess insulin in some form is the ‘final common pathway’ for the overwhelming majority of them. Block it, and the fat cells remain empty.
Robert Lustig
Fructose isn’t the only cause of obesity, but it is the primary cause of chronic metabolic disease, which kills . . . slowly.
Robert Lustig

Big Butt Fat vs. Belly Fat

“Whenever we step on the scale, we are measuring the sum of four different body compartments, only one of which is bad for us.

  1. 1. Bone. The more bone the longer you live. …
  2. 2. Muscle. More muscle is better for your health. Muscle takes up glucose. More exercise means more muscle, and more muscle means better insulin sensitivity. … When you are building bone and muscle, you are providing a method for burning energy rather than storing it, which leads to improving your health regardless of your weight.
  3. 3. Subcutaneous (or ‘big butt’) fat. This makes up about 80 percent of our total body fat and is what gave Marilyn Monroe her hourglass figure. Believe it or not, more subcutaneous fat is better for your health. …
  4. 4. Visceral fat. The only compartment that is consistently bad for us is our visceral (aka abdominal, ectopic, or ‘big belly’ fat. This consists of fat in areas where it doesn’t belong, including fat inside your abdomen and inside your organs (e.g., liver and muscle). It makes up about 20 percent of our total body fat, or about 4-6 percent of our total body weight. Visceral fat is the fulcrum on which your health teeters.”

As Lustig tells us: “Not all pounds are created equal.”

Big butt fat? Science says that’s much better than big belly fat. (lol)

It’s the VISCERAL fat that’ll kill us. “When it comes right down to it, it’s all about your middle. This whole obesity/health/longevity question centers on your abdominal, visceral, or ‘big belly’ fat—at least statistically.”

And: The simplest and cheapest surrogate for determining your health status is your waist circumference, which correlates with morbidity and risk for death better than any other health parameter. This is arguably the most important piece of information in your entire health profile because it tells you about your visceral fat. A high waist circumference translates into the ‘apple’ shape that tips physicians off to risk for diabetes, heart disease, stroke, and cancer.”

The best way to get a sense of your waist circumference? Your belt size. Lustig tells us that more than 40 inches for men and 35 inches for women is a likely indicator of visceral fat.

Private question time: What’s YOUR belt size?

In a nutshell, your body fat is your biggest long-term risk for infirmity. Nothing correlates with diabetes, heart disease, and cancer better than your fat.
Robert Lustig

Why so many diets work (Hint: Less sugar + lots of fiber)

“Can low-fat and low-carb diets both be right? Or both wrong? What do the Atkins diet (protein and fat), the Ornish diet (vegetables and whole grains), and the traditional Japanese diet (carbohydrates and protein) have in common? On the surface they seem to be diametrically opposite. But they all have one thing in common: they restrict sugar. Every successful diet in history restricts sugar. Sugar is, bar none, the most successful food additive known to man. When the food industry adds it for ‘palatability,’ we buy more. And because it’s cheap, some version of sugar appears in virtually every processed foodstuff now manufactured in the world. Sugar, and specifically, fructose, is the Lex Luthor of this story.”

That’s from a chapter called “Fructose—The ‘Toxin.’”

Ever wonder why diets that are so different on the surface can all get such great results?

Well, Lustig walks us through why diets like Atkins, Ornish, Paleo, and the traditional Japanese diet all work. Some are low carb and high fat. Others are high carb and low fat.

It’s simple. They all reduce sugar.

Well, technically, later in the book he tells us all those diets that work also all have fiber: “Let’s look at all these diets. Some rely on fat for energy, others rely on carbohydrates for energy, and some use both. Yet they all work to control weight and improve metabolic health, and have been shown to reduce heart disease. What do they all share? Two things. They are all low in sugar, and they are all high in fiber (and therefore high in micronutrients). We’ve arrived. That’s the point—that’s what matters. You now hold the keys to the kingdom. Naturally occurring fructose comes from sugarcane, fruits, some vegetables, and honey. The first three have way more fiber than fructose, and the last is protected by bees. Nature made sugar hard to get. Man made it is easy to get. And that’s the nugget of truth that the food industry and the U.S. government won’t admit; because if they did, they’d have to scale back. And they either can’t or don’t want to. That’s why the rates of obesity and chronic metabolic disease have skyrocketed wherever the industrial global diet has been introduced.”

Fiber is half the solution. Exercise is the other. We’ll take a quick look at that in a moment.

But, first: Do you (and your kids) drink fruits juices? If so, stop. They’re as bad as sodas. (And I hope you’ve already stopped consuming those as they’re pure added sugar which is no bueno.)

“The health-conscious among you may opt for juice over soda. For those of you who can afford it, you skip the Sunny Delight in favor of ‘natural 100 percent fruit juices’ made by Odwalla or other organic companies. They tout multiple health benefits and claim that, because they are devoid of sweeteners, they are in fact good for you. Wrong. The fruit is good for you, because it also contains fiber. In fact, calorie for calorie, 100 percent orange juice is worse for you than soda, because the orange juice contains 1.8 grams of fructose per ounce, while the soda contains 1.7 grams of fructose per ounce.”

In other words: DROP the orange juice from the breakfast menu and the Odwalla from the “healthy” snack menu. And, at the risk of bursting one too many bubbles, skip the fruit smoothies as well. “The problem is that the shearing action of the blender blades completely destroys the insoluble fiber of the fruit. … The sugar in the fruit will be absorbed as fast as if the juice were strained with no fiber at all.”

As you will see, all successful diets share three precepts: low sugar, high fiber (which means high micronutrients), and fat and carbohydrate consumed together in the presence of an offsetting amount of fiber. Anything after that is window dressing.
Robert Lustig
Fructose. Finally, we come to the Voldemort of the dietary hitlist: the sweet molecule in sugar. If it’s sweet, and it’s caloric, it’s fructose. Period. This is the one foodstuff whose consumption has increased worldwide, and with reckless abandon. And it is the one that children eat with no holds barred. We have animal and human data. We also have the golden ticket: correlation *and* causation. Every age group, including infants, has increased its consumption of fructose in the last thirty years. As far as I am concerned, this is where the action is.
Robert Lustig

The best deal of medicine: Exercise

“Irrespective of weight, consistent exercise (even just fifteen minutes a day) is the single best way for people to improve their health. That’s 273 hours paid in for 3 years of life gained, or a 64,000 percent return on investment. The best deal of medicine.”

That’s from a chapter all about the extraordinary benefits of exercise.

One thing to remember: It’s all about CONSISTENCY! Lustig tells us: “Studies demonstrate that all the levels of PPAR-gamma coactivator 1-alpha (PGC-1a; the protein in muscle cells that turns on all the good muscle metabolic effects and tells the mitochondria to divide) decline within a day of cessation of exercise, and insulin sensitivity returns to baseline within fifteen days. So, those of you weekend warriors who think you’re doing yourself some good—it may not be as good as you think. If you’re going to use exercise as your protection against chronic diseases, you’ll have to be consistent about it.”

In Designed to Move, we talked about the negative metabolic effects of sitting for longer than half an hour! Moral of the story: Get up. Move. All day. And exercise daily. Repeat.

Voting with every dollar we don’t spend

“Reducing sugar consumption will not be easy—particularly in the emerging markets of developing countries, where soft drinks are cheaper than milk or potable water. Social intervention is needed to reduce the supply and eventual demand for sugar. Despite the obvious medical, social, and economic benefits, we face an uphill political battle against a powerful sugar and food processing lobby, and against those in government who are already corrupted. Any change will require active engagement from all stakeholders. And that means you. Especially you. With enough public clamor, tectonic shifts in policy do become possible. Take, for instance, bans on smoking in public, the use of designated drivers, airbags in cars, and condom dispensers in public restrooms. All unfathomable thirty years ago. Your voice changed the world. It can be a new world . . . yet again.”

Those are the last words of the book from a section in which Lustig walks us through the public policy challenges of shifting our consumption of sugar.

Although sugar has become a more and more obvious toxin in our modern lives, it’s going to be tough to shift our consumption patterns and slow down the growing global pandemic. Too many powerful lobbies have too much control to make the shift easy.

Which is where we come in. Let’s vote with every dollar we don’t spend on the junk food and add our vibrant, energized voice to the movement!

Ninety percent of the food produced in the United States is sold to you by a total of ten conglomerates—Coca-Cola, ConAgra, Dole, General Mills, Hormel, Kraft, Nestle, Pepsico, Proctor and Gamble, and Unilever.
Robert Lustig

About the author

Authors

Robert Lustig

Physician, Author of Fat Chance, Hacking of the American Mind: The Science Behind the Corporate Takeover of Our Bodies and Brains